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Sm (non recombinant; bovine)/Sm（非重组；牛）

产品分类 > 自免疾病检测原料 > Sm (non recombinant; bovine)/Sm（非重组；牛）

Sm (non recombinant; bovine)/Sm（非重组；牛）

产品货号：17500/17501

促销：￥0.00

分享到：

产品规格：

0.1mg 1mg

供应商：

德国Diarect

详细介绍

Diseases:
Systemic Lupus Erythematosus (SLE)

Anti-Sm antibodies are highly specific for SLE and are therefore recorded in the classification criteria of the American College of Rheumatology. Anti-Sm antibodies are found in 5 - 30% of patients with SLE, the frequency varying on the detection system and the selection criteria for study cohorts. Also, a racial difference in the incidence of anti-Sm antibodies has been shown.

The Sm antigen is part of the spliceosomal complex catalyzing the splicing of nuclear pre-mRNA. Each spliceosome snRNP consists of snRNAs (U1, U2, U4/U6, and U5) bound to a unique set of proteins as well as a shared set of seven different Sm proteins with molecular weights between 9 and 29.5 kDa (typically SmB/SmB, SmD1, SmD2, SmD3, SmE, SmF, SmG). Most frequently the SmB and SmD polypeptides are targets of the anti-Sm specific autoimmune response, of which SmD is regarded the most SLE-specific Sm antigen.

Sm (non recombinant; bovine) from DIARECT is purified from bovine tissue.

相关疾病：系统性红斑狼疮（SLE）

系统性红斑狼疮(Systemic Lupus Erythematosus; SLE)是一种以免疫调节障碍为特征的自身免疫性疾病，会引起抗核抗体的产生、循环免疫复合物的再生，并且能激活补体系统。
   抗Sm抗体是系统性红斑狼疮的高特异性抗体，所以被美国风湿病学会的分类标准收录。5-30%的SLE患者中存在抗Sm抗体，出现的频率随检测系统和研究组的择入标准而不同。研究同样指出抗Sm抗体的发生率存在种族差异。
   Sm抗原是剪接体复合物的一部分，催化核mRNA前体的剪接。每个剪接体snRNP包含的snRNAs (U1, U2, U4/U6和U5)结合一组独特的蛋白质，共享一套七个不同的Sm蛋白(SmB/SmB, SmD1, SmD2, SmD3, SmE, SmF和SmG)，它们分子量在9到29,5kDa之间。SmB和SmD多肽是最常见的抗Sm特异性自身免疫应答标靶，其中SmD被看作是最主要的SLE特异性的Sm抗原。
    除了重组SmD蛋白（在精氨酸上SmD1和SmD3对称二甲基化）以外，Diarect现在还提供牛源的Sm抗原（非重组）。DIARECT生产的Sm（非重组，牛）是从牛组织中纯化的。