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产品分类 > 自免疾病检测原料 > DNA Topoisomerase I (Scl-70; non recombinant; bovine)/DNA拓扑异构酶I (Scl-70; 非重组; 牛)

DNA Topoisomerase I (Scl-70; non recombinant; bovine)/DNA拓扑异构酶I (Scl-70; 非重组; 牛)

产品货号:11500/11501
促销: 0.00

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0.1mg 1mg
德国Diarect

Diseases:
Scleroderma

DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in scleroderma patients (specificity 98-100%) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis.
In human tissues the DNA topoisomerase I is initially synthesized as a protein with a molecular weight of 100 kDa. Most of this precursor is then proteolytically processed to a 70-kDa size, from which the Scl-70 antigen has derived its name.

To allow optimal assay development DIARECT offers three distinct DNA topoisomerase I antigens: 

the non recombinant, bovine DNA Topoisomerase I antigen,

recombinant, full-length 100-kDa enzyme precursor and

recombinant, truncated form resembling the processed 70-kDa form of the antigen.

DNA Topoisomerase I (non recombinant; bovine) from DIARECT is purified from bovine tissue.

Availability on request. Please inquire.