Polymyositis and Dermatomyositis
PM/Scl 75 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against PM/Scl 75 occur in patients suffering from polymyositis, scleroderma or polymyositis / scleroderma overlap syndromes.
PM/Scl 100 as well as PM/Scl 75 are available from DIARECT.
PM/Scl 75 from DIARECT is produced in the baculovirus / insect cell expression system.