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产品分类 > 乳糜泻(麸质过敏症) > Gliadin (recombinant; deamidated)麦胶蛋白

Gliadin (recombinant; deamidated)麦胶蛋白

产品货号:19500/19501
促销: 0.00

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0.1mg 1mg
德国Diarect

Diseases:Celiac Disease

Celiac disease is a chronic gastrointestinal disorder most probably caused by an abnormal immune reaction to wheat gliadin and related gluten components from barley, rye and possibly oats.

The disease is characterized by flattening of the jejunal mucosa and intestinal lesions of variable severity in genetically predisposed individuals. Celiac disease does not fit the typical characteristics of an autoimmune disease; yet is associated with anti-tissue transglutaminase antibodies. Nevertheless, monitoring of gliadin antibodies is recommended in screening populations at risk for CD and other gluten-sensitive enteropathies.

Historically, serologic tests for gliadin antibodies generally lacked the accuracy required for proper diagnosis due to missing deamidated epitopes within the authentic gliadin fraction traditionally used in diagnostic test kits.

As a protein-focused biotech enterprise, DIARECT has successfully completed the recombinant protein approach by designing and producing a deamidated γ-gliadin isoform. By sequence design the epitopes correspond to the deamidated neo-epitopes, which in the natural antigen are formed by transglutaminase-mediated glutamine side chain deamidation.

Gliadin from DIARECT is produced in E. coli.

 

 

相关疾病:麸质过敏症
 麸质过敏症又叫做乳糜泻,是指在遗传性的易感个体中,一种在小肠炎症条件下导致的对摄入一定的饮食谷蛋白——麦醇溶蛋白过敏症。该疾病的发病机制来自环境的,遗传的和免疫的因素的相互作用的结果。对该种病人唯一的治疗办法就是终生禁止含麦醇溶蛋白食物的饮用,这样能使肠黏液得到恢复。组织型谷氨酰胺转移酶做为抗原可检测出自身抗体,促使发病机制得到更好的理解并且促进了重要的血清学测试的发展。
麸质过敏症是一种慢性胃肠道紊乱疾病,很可能是由对小麦醇溶蛋白以及大麦,黑麦和燕麦相关麸质成分引起的异常的免疫反应造成的。
 这种疾病的特点是在遗传易感的个体中,患者的空肠黏膜变平和不同程度的肠损伤。麸质过敏症没有自身免疫性疾病的典型特征,但仍与抗组织转谷氨酰胺酶抗体有关。尽管如此,仍建议监测麦胶蛋白来筛查CD和其他麸质过敏的肠病高危人群。
 在以往的检测中,对麦胶蛋白抗体的血清学检测缺少精确性,没有合适的诊断方法,由于传统诊断检测试剂盒中使用的可信麦胶蛋白无去酰胺基的抗原表位。
作为以专注于蛋白质的生物技术企业,DIARECT通过对去酰胺基的序列设计和生产去酰胺基的γ-麦胶蛋白亚型成功地获得了重组蛋白的新抗原表位,而在天然抗原是谷氨酰胺转胺介导的谷氨酰胺侧链去酰胺基形成的。

DIARECT生产的醇溶蛋白是在大肠杆菌中表达的。