IA-2 (ICA 512)

IA-2 (ICA 512)

Insulinoma-associated protein (IA-2), also called islet cell antigen 512 (ICA 512), is a catalytically inactive protein tyrosine phosphatase (PTP)-like protein and a major target of autoimmune response in diabetes mellitus. The long C-terminal intracellular tail, harbors the majority of autoantibody epitopes. IA-2 is expressed within secretory granules in neural, neuroendocrine and pancreatic islet cells.