Natural Bet v 1 白桦过敏原Bet v 1

Birch pollen (Betula pendula)  

From birch pollen extract by multi-step chromatography.

Purity > 95 % by silver stained SDS-PAGE

See product insert.

Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.

Store at -20ºC.  Avoid repeated freeze-thaw cycles.

Purified natural Bet v 1 appears as a triplet of 18-20kD proteins representing distinct isoforms of Bet v 1 (1).

1. Batard, T. et al: Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy. Int Arch Allergy Immunol 2005, 136 (3), 239-249.

2. Breiteneder, H.et al: The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J 1989, 8 (7), 1935-1938.

3. Spangfort, M. D.et al:Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol 2003, 171 (6), 3084-3090.

4. Swoboda, I.et al: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995, 270 (6), 2607-2613

5. Vieths, S et al.: Establishment of recombinantmajor allergens Bet v 1 and Phl p 5a as Ph. Eur. Reference standardsand validation of ELISA methods for their measurement. Pharmeuropa Bio & SN 2012; 118-13.