Recombinant Bet v 1 重组白桦过敏原Bet v 1
Recombinant Bet v 1 重组白桦过敏原Bet v 1
| Allergen: | rBet v 1 (Betula pendula allergen 1.0101) |
| Unit: | 250µg |
| Source: | Pichia pastoris |
| Mol. Wt: | 18kD |
| Purification: | Purified from Pichia pastoris culture by HPLC gel filtration. Purity >95 % by silver stained SDS-PAGE |
| Concentration: | See product insert. |
| Formulation: | Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Steriled filtered. |
| Storage: | Store at -20ºC. |
| Notes: | Avoid repeated freeze-thaw cycles |
| Genbank: | |
| PDB: | |
| Product Resources: | Recombinant Bet v 1 Certificate of Analysis |
| Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use. | |
| References: | |
Batard, T. et al: Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy. Int Arch Allergy Immunol 2005, 136 (3), 239-249. | |
Breiteneder, H.et al: The gene coding for the major birch pollen allergen Bet v 1, is highly homologous to a pea disease resistance response gene. EMBO J 1989, 8 (7), 1935-1938. | |
Spangfort, M. D.et al: Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol 2003, 171 (6), 3084-3090. | |
Swoboda, I.et al: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995, 270 (6), 2607-2613. | |
S. Vieths et al.: Establishment of recombinant major allergens Bet v 1 and Phl p 5a as Ph. Eur. Reference standards and validation of ELISA methods for their measurement. Pharmeuropa Bio & SN 2012; 118-13. | |
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