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产品分类 > 皮屑毛发羽毛过敏原 > Natural Fel d 1 (NA-FD1-1)

Natural Fel d 1 (NA-FD1-1)

产品货号:NA-FD1-1
促销: 9200.00
价格: 9200.00

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250ug
美国Indoor
Allergen:nFel d 1 (Felis domesticus allergen 1)

Unit:250µg

Source:cat hair

Mol. Wt:18 kD

Purification:

Purified from cat hair extract by affinity chromatography. Purity approx. 95%.

Concentration:See product insert. 

Formulation:

Preservative and carrier-free in endotoxin free phosphate buffered saline, pH 7.4. Filtered through 0.22µm filter.

Storage:Store at -20ºC

Notes:(1) Because Fel d 1 is glycosylated, it migrates as a diffuse band on SDS-PAGE.

PDB:1PUO1ZKR2EJN

Product Resources:

Natural Fel d 1 Certificate of Analysis

Focus on... Fel d 1

Allergens are provided for research and commercial use in vitro:  not for human in vivo or therapeutic use.

References:


  1. Chapman MD, Aalberse RC, Brown MJ, Platts-Mills TAE. Monoclonal antibodies to the major feline allergen, Fel d I: II. Single step affinity purification of Fel d I, N-terminal sequence analysis and development of a sensitive two-site immunoassay to assess Fel d I exposure. J Immunol 1988: 140:812-818.

  2. Luczynska CM, Li Y, Chapman MD, Platts-Mills TAE. Airborne concentrations and particle size distribution of allergen derived from domestic cats (Felis domesticus). Amer Rev Respir Dis 1990: 141:361-367.

  3. Vailes LD, Li Y, Bao Y, DeGroot H, Aalberse RC, Chapman MD. (1994). Fine specificity of B-cell epitopes on Felis domesticus allergen I (Fel d 1): Effect of reduction and alkylation, or deglycosylation on Fel d I structure and antibody binding. J Allergy Clin Immunol 93:22-33.

  4. Kaiser L, Velickovic TC, Badia-Martinez D, Adedoyin J, Thunberg S, Hallen D, Berndt K, Gronlund H, Gafvelin G, van HM, Achour A. Structural Characterization of the Tetrameric form of the Major Cat Allergen Fel d 1. J Mol Biol, 2007;370:714-727.

  5. Hulse KE, Reefer AJ, Engelhard VH, Satinover SM, Patrie JT, Chapman MD, Woodfolk JA. Targeting Fel d 1 to FcgammaRI induces a novel variation of the T(H)2 response in subjects with cat allergy. J Allergy Clin Immunol, 2008;121:756-762.