Ro/SS-A (60 kDa; non-recomb.; bovine)/Ro/SS-A (60 kDa; 非重组;牛)

 Ro/SS-A (60 kDa; non-recomb.; bovine)

Diseases：
Systemic Lupus Erythematosus (SLE)
Sjøgren Syndrome, Subacute Cutaneous LE 

The Ro/SS-A antigen is a ribonucleoprotein complex and consists of two major proteins of 52 and 60 kDa, complexed with one specific RNA chain (either hY1, hY2, hY3 or hY5, which all are transcripts of RNA polymerase III); the Ro/SS-A (60 kDa) protein is the RNA-binding protein in the complex. The cellular function of this complex is still unresolved, as is the question whether the antigen is primarily located in the cytoplasm or in the nucleus or even shuttles between the 2 compartments.

Ro/SS-A antibodies occur with a prevalence of 60-90% in Sjøgren syndrome patients, but also with a prevalence of 25-50% in SLE patients and higher prevalences in subacute cutaneous LE patients. Neonatal lupus syndrome (congenital heart block, photosensitivity, skin lesions) is also associated with the presence of Ro/SS-A autoantibodies in the maternal and neonatal sera, in particular when these autoantibodies are directed to the 52-kDa antigen. 

Ro/SS-A (60 kDa; non recomb.; bovine) from DIARECT is purified from calf thymus.
 

相关疾病：系统性红斑狼疮（SLE），干燥综合征，亚急性皮肤型红斑狼疮Ro/SS-A抗原是一个核糖体核蛋白复合体，包含两个主要的蛋白，分子量分别为52和60kDa，与一个特异RNA链（hY1, hY2, hY3 或hY5中的任一个。它们都是RNA聚合酶III的转录物）复合；Ro/SS-A（60kDa）在复合物中是RNA结合蛋白。这个复合物的细胞功能还未了解，抗原初始是位于胞质或核内，或是在这两个空间中穿梭都还存在疑问。Ro/SS-A抗体存在于60-90%的干燥综合征患者当中，及25-50%的SLE的患者中，在亚急性皮肤型红斑狼疮患者中的存在率还要更高些。新生儿红斑狼疮（先天性心脏传导阻滞）也同样与母体和新生儿中Ro/SS-A自身抗体的存在相关，特别是当这些自身抗体指向52kD的抗原时。

DIARECT产的Ro/SS-A (60 kDa; non recombinant; bovine)是从小牛胸腺中纯化的。