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Natural Der p 1 屋尘螨过敏原Der p 1

产品分类 > 屋尘螨过敏原 > Natural Der p 1 屋尘螨过敏原Der p 1

Natural Der p 1 屋尘螨过敏原Der p 1

产品货号：NA-DP1-1

促销：￥8720.00

价格：￥8720.00

分享到：

产品规格：

250ug

供应商：

美国Indoor

详细介绍

Allergen:	nDer p 1 (Dermatophagoides pteronyssinus allergen 1)
Unit:	500µg
Source:	D.pteronyssinus culture medium
Mol. Wt:	24 kD
Purification:	From mite culture by affinity chromatography. Purity on silver stained SDS-PAGE >90%
Concentration:	See package insert. Based on Advanced Protein Assay. (Cytoskeleton Inc., Denver, CO)
Formulation:	Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.
Storage:	Store at -20ºC
Notes:	(1) Not tested for endotoxin. (2) Similar nDer p 1 preparations have been used in studies to analyze the cysteine protease activity of Der p 1, for T cell proliferation studies and antibody binding.
PDB:	1XKG, 2AS8, 3F5V X-ray crystal structures
Product Resources:	Natural Der p 1 Certificate of Analysis
Related products:	LTN-DP1-1 LoTox™ Natural Der p1 LTR-DP1D-1 LoTox recombinant Der p 1, deglycosyated RP-DP1D-1 Recombinant Der p 1, deglycosylated EL-DP1 Der p 1 ELISA 5H8/4C1 EL-DP1A Der p 1 ELISA 10B9/5H8 MA-5H8-1 5H8 anti Der p 1 MA-4C1-1 4C1 anti Der p 1, Der f 1 MA-10B9-1 10B9 anti Der p 1 BI-4C1-1 Biotinylated 4C1 anti Der p 1, Der f 1 BI-5H8-1 Biotinylated 5H8 anti Der p 1 ST-UAS Universal Allergen Standard
For Research Use Only: Not for Diagnostic or Therapeutic Use
References:
Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360.
Hewitt CRA, Brown AP, Hart BJ, Pritchard DL. A major house dust mite allergen disrupts the Immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995;182:1537-1544.
Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194.
King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651.
Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901.
Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133.
Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530.